Researchers used sensitive tracing methods to determine if the transplanted cells were capable of migrating to the cochlea and evaluated whether the cells could contribute to regenerating neurons and sensory tissue in the cochlea.
"Our findings show dramatic repair of damage with surprisingly few human-derived cells having migrated to the cochlea," said Roberto P. Revoltella, MD, PhD, lead author of the study. "A fraction of circulating HSC fused with resident cells, generating hybrids, yet the administration of HSC appeared to be correlated with tissue regeneration and repair as the cochlea in non-transplanted mice remained seriously damaged."
Results also showed that cochlear regeneration was less in the transplanted group deafened by noise rather than chemicals, implying that damage was more severe when induced by noise. Regenerative effects were greater in mice injected with a higher number of HSC. They also found that regeneration of cochlear tissues improved as time passed.
According to Revoltella, their results suggest the possibility of an "emerging strategy for inner ear rehabilitation….providing conditions for the resumption of deafened cochlea."
This can only mean one thing and that this particular study will surely speed up the date to the day when hearing loss in humans can ultimately be cured by those with sensorineural hearing loss (i.e. nerve deafness). For the 30 million people in the United States with hearing loss, this is great news. Except, perhaps, not for some of the 900,000 cultural deaf people who sees this news as a "threat" to their cultural ideals.
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