Dream Team of Scientists Collaborate on Cure for Hearing Loss in Ten Years

Looks like a goal is set by a dream team of stem cell scientists and researchers for hearing loss that sensorineural (nerve deafness) hearing loss would be cured through biological means in ten years from now.

The Hearing Restoration Project (HRP) is a Consortium made up of some of the most talented, creative, inspired researchers in the area of cell regeneration in the ear, both mid-level and senior-level investigators whose work has already contributed significantly to the field. The Consortium is an alliance of scientists working collaboratively and interactively with the goal of developing a biologic cure for severe sensorineural hearing loss in the next decade. At the Summit, experts discussed an area of particular promise: hair cell regeneration in humans.


"Hearing Health Foundation understands that it is important to invest in researchers who are working in hair cell regeneration as this will be an important component in the next wave of hearing treatments," said Andrea Boidman, Executive Director of Hearing Health Foundation. "Hearing research needs to be a national priority, and people need to know that there are treatments on the horizon that could really impact their lives."

In fact, a summit was held in New York city today.

Hearing Restoration Initiative 2011 Summit
The Promise of Cell Regeneration
On Monday, October 3, 2011, DRF will host a Summit on Hearing Restoration at the New York Academy of Medicine, at 103rd Street and 5th Avenue in New York City. As a part of DRF's Hearing Restoration Initiative, this landmark summit brings together the leaders in the field of cell regeneration research in the ear to discuss what it is, where it is going and how one day soon a therapy for cell regeneration in the ear will be a reality.


Doors open at 12pm.
Exhibit Hall hours 12pm to 6pm


Exhibitors include:
- AARP - Caption Call - Caption First


This event is open to the public. Online registration has closed, but you will be able to register on-site.


ASL and CART services will be provided.
For more information, please contact Melody Seiling at mseiling@drf.org.

That's pretty ambitious to say that a biological cure using stem cells for sensorineural hearing loss would happen in ten years time. Certainly would be loads better than an Esteem implantable hearing aid.

Cure for nerve deafness gets even closer

One step closer on the goal to help restore hearing loss.

A cure for deafness could be on the horizon after scientists created specialised ear cells in the lab.

Grown in their thousands, the delicate hairs could one day be transplanted into the inner ear, restoring hearing to millions.

The breakthrough comes after ten years of painstaking research.

It may also allow some balance disorders to be eased and aid the search for drugs to prevent people from becoming hard of hearing.

Age-related hearing loss affects half of Britons aged 60 and over and there is currently no way of holding it at bay.

Hearing aids amplify sounds but nothing can give sufferers back the hearing they once had.

In the latest research at Stanford University, California, scientists perfected turning stem cells - blank cells which can turn into other cell types - into the delicate hairs found in the inner ear. ones.

The linch-pin of hearing and balance, thousands of these hairs help convert sound vibrations into nerve impulses which are decoded by the brain.

Ageing, noise and general wear and tear make them wither away and, until now, there was no way of replacing them.

The hairs made in the lab from mice looked and acted like the real thing, the journal Cell reports.

Researcher Stefan Heller said: 'We knew it was really working when we saw them in the electron microscope.

'They looked more or less like they were taken out of the ear.'

If the same technique can be applied to human cells, within ten years it may be possible to transplant-the delicate hairs to restore hearing.

Using slivers of the patient's skin as a source of the stem cells means that any hairs generated would be a perfect match for their body.

It also raises the tantalising possibility of creating drugs to coax the ear into growing more hair cells of its own accord.

We may be only 10 years away on witnessing the impossible.

Read more: http://www.dailymail.co.uk/health/article-1278160/Deafness-cure-breakthrough-scientists-create-tiny-ear-hairs-stem-cells.html#ixzz1MIzLjDfu

Promising research continues for cure on hearing loss

For 2010, the American Hearing Research Foundation will be funding six grants. This year, we received the highest number of grant proposals in our history—41 proposals in all. The following grants will begin on January 1, 2010, and will be funded for $20,000 for one year.

Douglas Cotanche, Ph.D.
Boston University School of Medicine, Massachusetts
“Cell fate regulation in cochlear development and regeneration”

Birds can regenerate hair cells in the cochlea once they are lost – an ability that mammals do not possess. When hair cells are lost in birds, following loud noise exposure or administration of ototoxic drugs in the lab, the supporting cells around the hair cells turn into new hair cells. Cotanche and colleagues hope that by studying this process in birds, they will be able to induce the mammalian cochlear cells to undergo a similar regeneration. Specifically, the researchers will study the genetics involved in supporting cell transduction into hair cells in chicks and mice. They hope to gain understanding of the molecular processes involved in hair cell regeneration in order to cause the same regeneration in mammalian cells.

Saima Riazuddin, Ph.D.
Cincinnati Children’s Hospital Medical Center, Ohio
“Generation and characterization of a mouse model of DFNB26”

More than 100 gene locations have been indentified as contributing to hearing loss in its various forms. However, knowledge on how genes affect hearing remain inadequate. Researchers need to be able to study and develop animal models to study disease causing mutations, and to define the molecular pathways leading to hearing loss to ultimately develop therapeutic approaches to treating deafness. Riazuddin and colleagues have recently mapped a deafness causing gene called DFNB26 in an extended family. They also discovered another gene that that suppresses the deafness-causing gene. The researchers hope to study how these two genes work to cause and prevent deafness among the members of this family by developing mice with these genes. The study will provide valuable models for defining the role of DFNB26 in the inner ear and to develop treatment strategies for this disease.

Angelika Doetzlhofer, Ph.D.
Johns Hopkins University School of Medicine, Baltimore, Maryland
“Response of supporting cell to hair loss in the mammalian cochlea”

Doetzelhofer and colleagues hope to uncover the molecular signals activated in supporting cells after hair cell loss, and what pathways may inhibit hair cell regeneration. In mammals, hair cells only develop during embryonic development, and when hair cells are lost, they are not replaced. However, in birds, when hair cells are lost, supporting cells can transform into new hair cells. Researchers believe that supporting hair cells, even in mammals, have the ability to transform into hair cells, but that signals from adjacent cells and/or dying hair cells block supporting cells from becoming new hair cells. Doetzlhofer and colleagues will investigate these inhibitory pathways and will look at changes in gene expression in supporting cells as hair cells are lost. Understanding the molecular mechanisms that prevent hair cell regeneration in mammals is a crucial first stem in developing successful hair cell replacement therapies.

Proteins found to help develop auditory neurons

The leading cause of congenital and acquired hearing impairment is loss of spiral ganglion neurons or hair cells in the inner ear.

Researchers at the University of California, San Diego, School of Medicine and the National Institutes of Health found that Sox2, a protein that regulates stem cell formation, is involved in spiral ganglion neuron development. The study was published in the January 13 issue of the Journal of Neuroscience.

"These findings may provide the first step toward regenerating spiral ganglion neurons, the nerve cells that send sound representations to the brain," said Alain Dabdoub, PhD, co-investigator and assistant professor of surgery with the division of otolaryngology at the UC San Diego School of Medicine. "This has significant implications for advances in cochlear implant technology and biological treatments for hearing loss."

In the cochlea, auditory neurons transmit sound vibrations conveyed by hair cells. These vibrations are then converted to nerve impulses that communicate with the brain. If the neurons are lost or damaged, hearing loss occurs. Existing therapies for hearing loss are based on either increasing hair cell stimulation with hearing aids or introducing an electronic substitute for the hair cells with cochlear implants. In either case, the presence of functional spiral ganglion neurons is required for a successful outcome.

Prior research shows that as few as 10 percent of the normal number of spiral ganglion neurons is sufficient for the success of cochlear implants.

"The identification of factors that induce functional neurons has important implications for hearing restoration," said Chandrakala Puligilla, PhD, a research fellow at the National Institutes of Health. "The ability to induce even a small number of cells with gene-based therapy could be enormously beneficial."

Source: - read more.

Blinded by my own hearing

Not me but I was pleased to hear David Granovsky's comment in his blog "The Stem Cell Blog" when he covered the Chloe Sohl's story on her miraculous recovery from her hearing loss using her own adult stem cells. David went onto say that basically he forgot about people with hearing loss may unable to hear or understand fully what the original YouTube version of Chloe's story. And that he was "blinded" by his own hearing for not thinking about a captioned version of Chloe's video story.


Related Kokonut Pundit blogs on adult stem cells and hearing loss.

Video Interview (caption) with first American to have her hearing loss restored

Not fully restored so far but it looks like Chloe's hearing is on the mend already since this adult stem cells procedure began only a few months ago. Watch the video about a story that is probably the first case of an American woman that was successfully treated with her own adult stem cells to treat her hearing loss caused by her auto-immune resonse.




More info on the story.


YouTube's version without captions.

First Successful Case Example of a Hearing Loss Cure in a Human Patient?

With the slow progress and FDA approval in the United States on using stem cells to help treat nerve deafness hearing loss a patient with autoimmune condition hearing loss was treated in South Korea using her own adult stem cells that eventually restored her hearing to almost normal levels.

Chloe visited Dr. Won, a plastic surgeon in Los Angeles to harvest her fat tissue around her belly button in last June. Then the tissue was sent to the laboratory RNL BIO in Germantown, Maryland, where they isolated stem cells, put them in liquid nitrogen shipper and transported them to RNL BIO in Seoul, Korea. It took them a month to expand her stem cells to a sufficient amount enough to treat her hearing loss. Chloe's family planned a trip to Korea during their summer vacation. At last, on July 27, 2009, they visited Korea for two weeks. The stem cell treatment took place in Japan -- 600 million cells were administered by three injections with 5 day intervals. The cells were injected into her veins and auditory system.

Chloe's hearing was tested two months after the procedure was completed on October 16, 2009. The results were spectacular. The left side of her ear improved 50% from not being able to hear at all. The right side of her ear gained almost complete hearing.

Dr. Jotterand could not bear her excitement, "Now it's just been a 180 degree turnaround. She's just enjoying life and enjoying being a freshman at the university. She's just having a great time and it's just wonderful to see the joy in her own face and in her life."

Again, with a grain of salt but this looks more promising. With more countries such as Mexico taking part in using stem cells to began the treatment of nerve deafness hearing loss, the United States will surely be left in the dust at this rate unless the FDA somehow fast track this medical process just as they have fast tracked for the treatment of damaged heart muscles with the patient's own stem cells.

Hat tip: Neuro.

UPDATE: See caption video interview of Chloe!

First case of stem cell treatment on hearing loss on humans?

From what I've found there seems to be two patients with sensorineural hearing loss iare undergoing stem cell treatments in Mexico at the Nepsis Institute from a "Ask the Doctor" which seems to be on the edge of discovering how well these treatments will work in restoring some or all of the hearing nerves.

6) Are you or can you treat sensory neural hearing loss with adult autologous stem cells? If not, do you expect to in the next year? Do you know of any doctors treating hearing loss at this point, if Nepsis does not?

Actually, we have two patients with sensory neural hearing loss who will be undergoing stem cell treatment in the next two months. The approach is unique and proprietary, so I can’t get into specifics at this time.

In time we'll find out whether if this is a success or not and if so would prove ground-breaking so early in this game rather than 10 or 15 years down the road. As always, take this with a grain of salt.

Hat-tip: Neuro

Path to cure for sensorineural hearing loss explained

Here's WongTanLim3 blog that does a very good job breaking down the discussion on the path to cure sensorineural hearing loss and does a quick summary along with important links. Reading this blog you will realize that this particular biomedical field is now soon becoming into a race for the cure for hearing loss in the area of nerve deafness. This blog piece is a MUST READ! And a must have blog to add to your favorite link.

Like me, if you're following stem cell or gene therapy research for the treatment or cure for sensorineural hearing loss or nerve deafness which is one of the most promising field of medical research and development into the coming next decade, then this is a must read blog to read. And keep abreast of important news and thoughts like this recent blog post by WongTanLim3.

Be sure send a thank you to WongTanLim3 for keeping a sharp eye on this growing field soon to be a burgeoning biomedical development which will have the potential to affect several hundreds million people around the world with nerve deafness. Of course, this alone would have the greatest impact to those in the Deaf community when compared to the issues and consternations involving cochlear implants.

Cure for Hearing Loss One Step Closer....

Scientists were able to narrow down a key gene called Atoh1 (also known as Math1 - ) which cause cells to develop into hair cells but that these cells function like normal hair cells. So far, hearing loss may be repaired by cell transplantation using human umbilical cord Hematopoietic Stem Cells (HSC) since they show that a small number migrated to the damaged area inside the cochlea and repaired sensory hair cells and neurons.

Researchers used sensitive tracing methods to determine if the transplanted cells were capable of migrating to the cochlea and evaluated whether the cells could contribute to regenerating neurons and sensory tissue in the cochlea.

"Our findings show dramatic repair of damage with surprisingly few human-derived cells having migrated to the cochlea," said Roberto P. Revoltella, MD, PhD, lead author of the study. "A fraction of circulating HSC fused with resident cells, generating hybrids, yet the administration of HSC appeared to be correlated with tissue regeneration and repair as the cochlea in non-transplanted mice remained seriously damaged."

Results also showed that cochlear regeneration was less in the transplanted group deafened by noise rather than chemicals, implying that damage was more severe when induced by noise. Regenerative effects were greater in mice injected with a higher number of HSC. They also found that regeneration of cochlear tissues improved as time passed.

According to Revoltella, their results suggest the possibility of an "emerging strategy for inner ear rehabilitation….providing conditions for the resumption of deafened cochlea."

This can only mean one thing and that this particular study will surely speed up the date to the day when hearing loss in humans can ultimately be cured by those with sensorineural hearing loss (i.e. nerve deafness). For the 30 million people in the United States with hearing loss, this is great news. Except, perhaps, not for some of the 900,000 cultural deaf people who sees this news as a "threat" to their cultural ideals.

Deafness Cure One Step Closer.....

And, no, this isn't a fake news but a real one where scientists have gotten one step closer, very close I might add, to help solve an age old problem on how to restore hearing loss in deaf and hard of hearing people.

Deaf people could one day have their hearing restored through a ground-breaking gene therapy technique, scientists reported yesterday.

They showed that they can trigger the growth of new hair cells in the inner ear that are crucial to hearing as they pick up sound vibrations.

In tests on mice they showed that stimulating these usually irreplaceable cells to grow resulted in new cells that helped detect noise.

Researchers believe the approach could eventually be used to improve or restore hearing to the 9 million people in Britain classified as deaf or hard of hearing.

Dr. Mark Downs, of the Royal National Institute for Deaf People, said: "This is an exciting development which completes another important piece of the jigsaw in understanding how we might use gene therapy to eventually restore hearing loss.

"It is no longer a pipedream to talk about cell and drug-based solutions. There is a long way to go, but the journey towards new treatments is certainly under way."

Read more here. And even more details here.

Once scientists began to unravel certain key but crucial elements on how to unlock the mysteries of deafness by restoring hearing will only mean that the dominos will fall faster as more scientists join in on the search to finally help restore hearing loss. This news discovery today will only mean that research will step up even more quicker and the time til the first deaf person to have his/her hearing restored will be even more closer and not some distant pipe dream.

Amazing science!

And here's to for the restoration of hearing loss!